› 3lmg

X-ray diffraction
2.8Å resolution

Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP

Released:
DOI: 10.2210/pdb3lmg/pdb
PDB entry 3lmg coloured by chain, front view.
PDB entry 3lmg coloured by chain, side view.
PDB entry 3lmg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.
Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA
Proc Natl Acad Sci U S A 107 7692-7 (2010)
PMID: 20351256

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21860 (Residues: 684-1020; Coverage: 26%)
Gene names: ERBB3, HER3
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 193.348Å b: 47.981Å c: 82.224Å
α: 90° β: 108.11° γ: 90°
R-values:
R R work R free
0.255 0.252 0.285
Expression system: Spodoptera frugiperda

Quick links

Citations

104 review citations

The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R. (2014)
103 more

16 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
15 more