› 3lof

X-ray diffraction
2.4Å resolution

C-terminal domain of human heat shock 70kDa protein 1B.

Released:
DOI: 10.2210/pdb3lof/pdb
PDB entry 3lof coloured by chain, front view.
PDB entry 3lof coloured by chain, side view.
PDB entry 3lof coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Osipiuk J, Gu M, Mihelic M, Orton K, Morimoto RI, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock 70 kDa protein 1A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 113 amino acids
Theoretical weight: 11.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DMV8 (Residues: 534-641; Coverage: 17%)
Gene names: HSP72, HSPA1, HSPA1A, HSX70
Structure domains: Substrate Binding Domain Of Dnak; Chain:A; Domain 2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P2221
Unit cell:
a: 70.702Å b: 71.88Å c: 143.159Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.235
Expression system: Escherichia coli BL21(DE3)

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