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Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

Source organism: Homo sapiens
Biochemical function: kinase activity
Biological process: phospholipid biosynthetic process
Cellular component: cytosol

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EC 2.7.1.82: Ethanolamine kinase

Reaction catalysed:
ATP + ethanolamine = ADP + O-phosphoethanolamine
Systematic name:
ATP:ethanolamine O-phosphotransferase
Alternative Name(s):
  • Ethanolamine kinase (phosphorylating)
  • Ethanolamine phosphokinase

EC 2.7.1.32: Choline kinase

Reaction catalysed:
ATP + choline = ADP + phosphocholine
Systematic name:
ATP:choline phosphotransferase
Alternative Name(s):
  • Choline kinase (phosphorylating)
  • Choline phosphokinase
  • Choline-ethanolamine kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01633
Domain description: Choline/ethanolamine kinase
Occurring in:
  1. Choline/ethanolamine kinase
The deposited structure of PDB entry 3lq3 contains 1 copy of Pfam domain PF01633 (Choline/ethanolamine kinase) in Choline/ethanolamine kinase. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Choline/ethanolamine kinase

Structure domains

CATH CATH domains
3.90.1200.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Homology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Occurring in:
  1. Choline/ethanolamine kinase
The deposited structure of PDB entry 3lq3 contains 1 copy of CATH domain 3.90.1200.10 (Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2) in Choline/ethanolamine kinase. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Choline/ethanolamine kinase
The deposited structure of PDB entry 3lq3 contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Choline/ethanolamine kinase. Showing 1 copy in chain A.

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