› 3lto

X-ray diffraction
2.27Å resolution

Crystal structure of a mevalonate diphosphate decarboxylase from Legionella pneumophila

Released:
DOI: 10.2210/pdb3lto/pdb
PDB entry 3lto coloured by chain, front view.
PDB entry 3lto coloured by chain, side view.
PDB entry 3lto coloured by chain, top view.
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Entry authors: Palani K, Burley SK, Swaminathan S, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mevalonate diphosphate decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 36.79 KDa
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5ZTW8 (Residues: 8-322; Coverage: 98%)
Gene name: lpg2040
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 71.738Å b: 88.824Å c: 104.241Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links