› 3lu7

X-ray diffraction
2.8Å resolution

Human serum albumin in complex with compound 2

Released:
DOI: 10.2210/pdb3lu7/pdb
PDB entry 3lu7 coloured by chain, front view.
PDB entry 3lu7 coloured by chain, side view.
PDB entry 3lu7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Buttar D, Colclough N, Gerhardt S, MacFaul PA, Phillips SD, Plowright A, Whittamore P, Tam K, Maskos K, Steinbacher S, Steuber H
Bioorg Med Chem 18 7486-96 (2010)
PMID: 20869876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand IPX 2 x IPX
Ligand PO4 5 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 58.541Å b: 59.185Å c: 95.603Å
α: 75.3° β: 87.86° γ: 75.51°
R-values:
R R work R free
0.236 0.225 0.276

Quick links

Citations

5 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
4 more