› 3lx7

X-ray diffraction
1.78Å resolution

Crystal structure of a Novel Tudor domain-containing protein SGF29

Released:
DOI: 10.2210/pdb3lx7/pdb
PDB entry 3lx7 coloured by chain, front view.
PDB entry 3lx7 coloured by chain, side view.
PDB entry 3lx7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J
EMBO J 30 2829-42 (2011)
PMID: 21685874

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SAGA-associated factor 29 Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96ES7 (Residues: 135-293; Coverage: 53%)
Gene names: CCDC101, SGF29
Sequence domains: SGF29 tudor-like domain
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand UNX 4 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 74.802Å b: 51.29Å c: 44.842Å
α: 90° β: 117.48° γ: 90°
R-values:
R R work R free
0.208 0.206 0.245
Expression system: Escherichia coli BL21

Quick links

Citations

52 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
51 more

1 mention without citation

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Bian et al. (2011)