› 3lxu

X-ray diffraction
3.14Å resolution

Crystal Structure of Tripeptidyl Peptidase 2 (TPP II)

Released:
DOI: 10.2210/pdb3lxu/pdb
PDB entry 3lxu coloured by chain, front view.
PDB entry 3lxu coloured by chain, side view.
PDB entry 3lxu coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Hybrid molecular structure of the giant protease tripeptidyl peptidase II.
Chuang CK, Rockel B, Seyit G, Walian PJ, Schönegge AM, Peters J, Zwart PH, Baumeister W, Jap BK
Nat Struct Mol Biol 17 990-6 (2010)
PMID: 20676100

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal tripeptide from a polypeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 28 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P41212
Unit cell:
a: 126.372Å b: 126.372Å c: 213.983Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.241 0.293
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Substrate recognition in selective autophagy and the ubiquitin-proteasome system.
Schreiber et al. (2014)
2 more

3 mentions without citation

Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns.
Malik et al. (2011)
2 more