› 3lyr

X-ray diffraction
2.51Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193728 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor COE1 Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 28.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UH73 (Residues: 10-250; Coverage: 41%)
Gene names: COE1, EBF, EBF1
Sequence domains: Transcription factor COE1 DNA-binding domain
Structure domains: Transcription factor COE1, DNA-binding domain

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
Ligand NH4 1 x NH4
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6522
Unit cell:
a: 134.218Å b: 134.218Å c: 72.391Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.233 0.274
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.
Boller et al. (2014)
2 more

3 mentions without citation

Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif.
Siponen et al. (2010)
2 more