› 3mlr

X-ray diffraction
1.8Å resolution

Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a NY5 V3 peptide

Released:
DOI: 10.2210/pdb3mlr/pdb
PDB entry 3mlr coloured by chain, front view.
PDB entry 3mlr coloured by chain, side view.
PDB entry 3mlr coloured by chain, top view.
Source organisms:
Primary publication:
Conserved structural elements in the V3 crown of HIV-1 gp120.
Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP
Nat Struct Mol Biol 17 955-61 (2010)
PMID: 20622876

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210524 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Truncated surface protein Chain: P
Molecule details ›
Chain: P
Length: 20 amino acids
Theoretical weight: 2.19 KDa
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
UniProt:
  • Canonical: P12490 (Residues: 296-315; Coverage: 5%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 42.414Å b: 43.076Å c: 58.212Å
α: 87.86° β: 85.5° γ: 85.82°
R-values:
R R work R free
0.181 0.181 0.216

Quick links

Citations

1 review citation

Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine.
Van Regenmortel MH. (2012)
98 other articles

7 mentions without citation

Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology.
Robinson JA. (2013)
6 more