› 3mlv

X-ray diffraction
2.48Å resolution

Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with an NOF V3 peptide

Released:
DOI: 10.2210/pdb3mlv/pdb
PDB entry 3mlv coloured by chain, front view.
PDB entry 3mlv coloured by chain, side view.
PDB entry 3mlv coloured by chain, top view.
Source organisms:
Primary publication:
Conserved structural elements in the V3 crown of HIV-1 gp120.
Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP
Nat Struct Mol Biol 17 955-61 (2010)
PMID: 20622876

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212459 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 219 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain Chains: H, N
Molecule details ›
Chains: H, N
Length: 226 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Envelope glycoprotein gp160 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 20 amino acids
Theoretical weight: 2.22 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: Q79790 (Residues: 174-193; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 42.554Å b: 42.745Å c: 116.063Å
α: 87.91° β: 85.22° γ: 85.97°
R-values:
R R work R free
0.239 0.233 0.342

Quick links

Citations

2 review citations

Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine.
Van Regenmortel MH. (2012)
1 more

3 mentions without citation

Frontal-executive dysfunction affects dementia conversion in patients with amnestic mild cognitive impairment.
Jung et al. (2020)
2 more