› 3mly

X-ray diffraction
1.7Å resolution

Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a UR29 V3 peptide

Released:
DOI: 10.2210/pdb3mly/pdb
PDB entry 3mly coloured by chain, front view.
PDB entry 3mly coloured by chain, side view.
PDB entry 3mly coloured by chain, top view.
Source organisms:
Primary publication:
Conserved structural elements in the V3 crown of HIV-1 gp120.
Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP
Nat Struct Mol Biol 17 955-61 (2010)
PMID: 20622876

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211637 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 214 amino acids
Theoretical weight: 22.66 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 230 amino acids
Theoretical weight: 24.47 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
HIV-1 gp120 third variable region (V3) crown Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 23 amino acids
Theoretical weight: 2.6 KDa
Source organism: Human immunodeficiency virus 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 59.948Å b: 128.787Å c: 60.096Å
α: 90° β: 92.54° γ: 90°
R-values:
R R work R free
0.182 0.181 0.215

Quick links

Citations

2 review citations

Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine.
Van Regenmortel MH. (2012)
1 more

4 mentions without citation

Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.
Hong et al. (2013)
3 more