› 3moq

X-ray diffraction
2.05Å resolution

Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks

Released:
DOI: 10.2210/pdb3moq/pdb
PDB entry 3moq coloured by chain, front view.
PDB entry 3moq coloured by chain, side view.
PDB entry 3moq coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.
Streltsov VA, Varghese JN, Masters CL, Nuttall SD
J Neurosci 31 1419-26 (2011)
PMID: 21273426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-138351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig-like domain-containing protein; P3(40) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 126 amino acids
Theoretical weight: 13.47 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q6X1E6 (Residues: 1-87, 102-113; Coverage: 88%)
  • Canonical: P05067 (Residues: 689-712; Coverage: 3%)
Gene names: A4, AD1, APP
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P32
Unit cell:
a: 79.653Å b: 79.653Å c: 85.457Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.19 0.249
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.
Masters et al. (2012)
13 more

8 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
7 more