› 3mpx

X-ray diffraction
2.8Å resolution

Crystal structure of the DH and PH-1 domains of human FGD5

Released:
DOI: 10.2210/pdb3mpx/pdb
PDB entry 3mpx coloured by chain, front view.
PDB entry 3mpx coloured by chain, side view.
PDB entry 3mpx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen Y, Nedyalkova L, Tong Y, Tempel W, Crombet L, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180590 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FYVE, RhoGEF and PH domain-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 434 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6ZNL6 (Residues: 889-1304; Coverage: 29%)
Gene names: FGD5, ZFYVE23
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand UNX 11 x UNX
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 38.14Å b: 70.645Å c: 127.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.289
Expression system: Escherichia coli BL21(DE3)

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