› 3mqc

X-ray diffraction
2.8Å resolution

Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21)

Released:
DOI: 10.2210/pdb3mqc/pdb
PDB entry 3mqc coloured by chain, front view.
PDB entry 3mqc coloured by chain, side view.
PDB entry 3mqc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Yang H, Wang J, Jia X, McNatt MW, Zang T, Pan B, Meng W, Wang HW, Bieniasz PD, Xiong Y
Proc Natl Acad Sci U S A 107 18428-32 (2010)
PMID: 20940320

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 121 amino acids
Theoretical weight: 13.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q10589 (Residues: 47-161; Coverage: 64%)
Gene name: BST2
Sequence domains: Bone marrow stromal antigen 2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 26.31Å b: 58.98Å c: 163.26Å
α: 90° β: 90.82° γ: 90°
R-values:
R R work R free
0.26 0.258 0.294
Expression system: Escherichia coli

Quick links

Citations

23 review citations

HIV Restriction Factors and Mechanisms of Evasion.
Malim et al. (2012)
22 more

9 mentions without citation

Functional landscape of SARS-CoV-2 cellular restriction.
Martin-Sancho et al. (2021)
8 more