› 3mrf

X-ray diffraction
2.3Å resolution

Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288 nonapeptide T4P variant

Released:
DOI: 10.2210/pdb3mrf/pdb
PDB entry 3mrf coloured by chain, front view.
PDB entry 3mrf coloured by chain, side view.
PDB entry 3mrf coloured by chain, top view.
Source organisms:
Entry authors: Trudel E, Gras S, Chouquet A, Debeaupuis E, Echasserieau K, Saulquin X, Bonneville M, Housset D

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137813 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-304; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
mRNA export factor ICP27 homolog Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 916 Da
Source organism: human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: Q3KSU1 (Residues: 300-308; Coverage: 2%)
Gene names: BMLF1, BSLF2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 51.622Å b: 79.392Å c: 55.661Å
α: 90° β: 112.02° γ: 90°
R-values:
R R work R free
0.189 0.186 0.257
Expression systems:
  • Escherichia coli
  • Not provided

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