› 3mrr

X-ray diffraction
1.6Å resolution

Crystal Structure of MHC class I HLA-A2 molecule complexed with Human Prostaglandin Transporter decapeptide

Released:
DOI: 10.2210/pdb3mrr/pdb
PDB entry 3mrr coloured by chain, front view.
PDB entry 3mrr coloured by chain, side view.
PDB entry 3mrr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans.
Reiser JB, Legoux F, Gras S, Trudel E, Chouquet A, Léger A, Le Gorrec M, Machillot P, Bonneville M, Saulquin X, Housset D
J Immunol 193 5816-26 (2014)
PMID: 25392532

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137824 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-304; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Solute carrier organic anion transporter family member 2A1 Chain: P
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 953 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92959 (Residues: 178-187; Coverage: 2%)
Gene names: OATP2A1, SLC21A2, SLCO2A1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 53.887Å b: 81.041Å c: 57.505Å
α: 90° β: 114.66° γ: 90°
R-values:
R R work R free
0.194 0.192 0.224
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Structural Prediction of Peptide-MHC Binding Modes.
Perez et al. (2022)
13 other articles

2 mentions without citation

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.
Song et al. (2017)
1 more