› 3mt5

X-ray diffraction
3Å resolution

Crystal Structure of the Human BK Gating Apparatus

Released:
DOI: 10.2210/pdb3mt5/pdb
PDB entry 3mt5 coloured by chain, front view.
PDB entry 3mt5 coloured by chain, side view.
PDB entry 3mt5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R
Science 329 182-6 (2010)
PMID: 20508092

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-171392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 726 amino acids
Theoretical weight: 81.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12791 (Residues: 406-1179; Coverage: 58%)
Gene names: KCNMA, KCNMA1, SLO
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C, NSLS BEAMLINE X29A
Spacegroup: P6322
Unit cell:
a: 144.518Å b: 144.518Å c: 182.195Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.246 0.278
Expression system: Spodoptera frugiperda

Quick links

Citations

50 review citations

Structure and function of TMEM16 proteins (anoctamins).
Pedemonte et al. (2014)
49 more

30 mentions without citation

BK channel activation: structural and functional insights.
Lee et al. (2010)
29 more