› 3mtg

X-ray diffraction
2.64Å resolution

Crystal structure of human S-adenosyl homocysteine hydrolase-like 1 protein

Released:
DOI: 10.2210/pdb3mtg/pdb
PDB entry 3mtg coloured by chain, front view.
PDB entry 3mtg coloured by chain, side view.
PDB entry 3mtg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wisniewska M, Siponen MI, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kotenyova T, Moche M, Nordlund P, Nyman T, Persson C, Schutz P, Thorsell AG, Tresaugues L, van der Berg S, Wahlberg E, Weigelt J, Welin M, Schuler H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
S-adenosylhomocysteine hydrolase-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 444 amino acids
Theoretical weight: 49.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43865 (Residues: 89-530; Coverage: 83%)
Gene names: AHCYL1, DCAL, IRBIT, XPVKONA
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2
Unit cell:
a: 186.24Å b: 68.6Å c: 90.37Å
α: 90° β: 115.27° γ: 90°
R-values:
R R work R free
0.204 0.203 0.249
Expression system: Escherichia coli BL21(DE3)

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