› 3mtx

X-ray diffraction
2Å resolution

Crystal structure of chicken MD-1

Released:
DOI: 10.2210/pdb3mtx/pdb
PDB entry 3mtx coloured by chain, front view.
PDB entry 3mtx coloured by chain, side view.
PDB entry 3mtx coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structure of soluble MD-1 and its interaction with lipid IVa.
Yoon SI, Hong M, Han GW, Wilson IA
Proc Natl Acad Sci U S A 107 10990-5 (2010)
PMID: 20534476

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187450 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lymphocyte antigen 86 Chains: A, B
Molecule details ›
Chains: A, B
Length: 151 amino acids
Theoretical weight: 17.07 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q90890 (Residues: 21-160; Coverage: 100%)
Gene names: LY86, MD1
Sequence domains: ML domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand PGT 2 x PGT
Ligand PGE 1 x PGE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 40.118Å b: 76.494Å c: 101.936Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.252
Expression system: Trichoplusia ni

Quick links

Citations

6 review citations

The structural biology of Toll-like receptors.
Botos et al. (2011)
5 more

4 mentions without citation

Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa.
Scior et al. (2013)
3 more