› 3mxt

X-ray diffraction
1.85Å resolution

Crystal Structure of Pantoate-Beta-alanine Ligase from Campylobacter jejuni

Released:
DOI: 10.2210/pdb3mxt/pdb
PDB entry 3mxt coloured by chain, front view.
PDB entry 3mxt coloured by chain, side view.
PDB entry 3mxt coloured by chain, top view.
Source organism: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Entry authors: Kim Y, Zhou M, Papazisi L, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192905 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.92 KDa
Source organism: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9PIK2 (Residues: 1-282; Coverage: 100%)
Gene names: Cj0297c, panC
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand GOL 2 x GOL
Ligand MG 1 x MG
Ligand SO4 1 x SO4
Ligand FMT 3 x FMT
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P6122
Unit cell:
a: 83.314Å b: 83.314Å c: 148.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.159 0.198
Expression system: Escherichia coli BL21

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