› 3naf

X-ray diffraction
3.1Å resolution

Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel (BK Channel)

Released:
DOI: 10.2210/pdb3naf/pdb
PDB entry 3naf coloured by chain, front view.
PDB entry 3naf coloured by chain, side view.
PDB entry 3naf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel.
Wu Y, Yang Y, Ye S, Jiang Y
Nature 466 393-7 (2010)
PMID: 20574420

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 798 amino acids
Theoretical weight: 89.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12791 (Residues: 394-1236; Coverage: 61%)
Gene names: KCNMA, KCNMA1, SLO
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I422
Unit cell:
a: 134.395Å b: 134.395Å c: 231.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.238 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

A BK (Slo1) channel journey from molecule to physiology.
Contreras et al. (2013)
26 more

38 mentions without citation

Carbon monoxide--physiology, detection and controlled release.
Heinemann et al. (2014)
37 more