› 3nau

X-ray diffraction
2.7Å resolution

Crystal structure of ZHX2 HD2 (zinc-fingers and homeoboxes protein 2, homeodomain 2)

Released:
DOI: 10.2210/pdb3nau/pdb
PDB entry 3nau coloured by chain, front view.
PDB entry 3nau coloured by chain, side view.
PDB entry 3nau coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.
Bird LE, Ren J, Nettleship JE, Folkers GE, Owens RJ, Stammers DK
BMC Struct Biol 10 13 (2010)
PMID: 20509910

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc fingers and homeoboxes protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 66 amino acids
Theoretical weight: 7.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6X8 (Residues: 444-501; Coverage: 7%)
Gene names: AFR1, KIAA0854, RAF, ZHX2
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 96.71Å b: 60.67Å c: 27.71Å
α: 90° β: 95.34° γ: 90°
R-values:
R R work R free
0.207 0.203 0.267
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Host Transcription Factors in Hepatitis B Virus RNA Synthesis.
Turton et al. (2020)
2 more

3 mentions without citation

ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer.
Fang et al. (2021)
2 more