› 3ni0

X-ray diffraction
1.6Å resolution

Crystal Structure of Mouse BST-2/Tetherin Ectodomain

Released:
DOI: 10.2210/pdb3ni0/pdb
PDB entry 3ni0 coloured by chain, front view.
PDB entry 3ni0 coloured by chain, side view.
PDB entry 3ni0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release.
Swiecki M, Scheaffer SM, Allaire M, Fremont DH, Colonna M, Brett TJ
J Biol Chem 286 2987-97 (2011)
PMID: 21084286

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 11.19 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R2Q8 (Residues: 53-151; Coverage: 58%)
Gene name: Bst2
Sequence domains: Bone marrow stromal antigen 2

Ligands and Environments

1 bound ligand:
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: I212121
Unit cell:
a: 33.685Å b: 100.831Å c: 110.432Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Host restriction factors in retroviral infection: promises in virus-host interaction.
Zheng et al. (2012)
13 more

4 mentions without citation

Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release.
Swiecki et al. (2011)
3 more