3nid

X-ray diffraction
2.3Å resolution

The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-209201 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (7 distinct):
Integrin alpha-IIb heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 457 amino acids
Theoretical weight: 49.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-488; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 471 amino acids
Theoretical weight: 51.96 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-497; Coverage: 62%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:
Monoclonal antibody 10E5 heavy chain Chains: E, H
Molecule details ›
Chains: E, H
Length: 221 amino acids
Theoretical weight: 23.77 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
Monoclonal antibody 10E5 light chain Chains: F, L
Molecule details ›
Chains: F, L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 258.97Å b: 144.49Å c: 104.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.215
Expression systems:
  • Cricetulus griseus
  • Not provided