Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Prolactin and Prolactin receptor (preferred)
PDBe Complex ID:
PDB-CPX-134123 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Prolactin
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Somatotropin hormone family
Structure domains: Growth Hormone; Chain: A;
Length: 199 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P01236 (Residues: 29-227; Coverage: 100%)
Sequence domains: Somatotropin hormone family
Structure domains: Growth Hormone; Chain: A;
Prolactin receptor
Molecule details ›
Chains: B, C
Length: 220 amino acids
Theoretical weight: 25.9 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 220 amino acids
Theoretical weight: 25.9 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P05710 (Residues: 20-229; Coverage: 36%)
Sequence domains:
Structure domains: Immunoglobulins
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID14-1
Spacegroup:
P43212
Expression system: Escherichia coli BL21(DE3)
