3nvn

X-ray diffraction
2.26Å resolution

Molecular mechanism of guidance cue recognition

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-129987 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Semaphorin-like protein 139 Chain: A
Molecule details ›
Chain: A
Length: 389 amino acids
Theoretical weight: 44.04 KDa
Source organism: Ectromelia virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8JL80 (Residues: 15-399; Coverage: 100%)
Gene names: EVM139, SEMA
Sequence domains: Sema domain
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Plexin-C1 Chain: B
Molecule details ›
Chain: B
Length: 476 amino acids
Theoretical weight: 51.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60486 (Residues: 35-507; Coverage: 31%)
Gene names: PLXNC1, VESPR
Sequence domains: Plexin repeat

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2221
Unit cell:
a: 95.749Å b: 133.494Å c: 172.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.276
Expression system: Homo sapiens