› 3nvx

X-ray diffraction
2Å resolution

Molecular mechanism of guidance cue recognition

Released:
DOI: 10.2210/pdb3nvx/pdb
PDB entry 3nvx coloured by chain, front view.
PDB entry 3nvx coloured by chain, side view.
PDB entry 3nvx coloured by chain, top view.
Source organism: Vaccinia virus Copenhagen
Primary publication:
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.
Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X
Cell 142 749-61 (2010)
PMID: 20727575

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Semaphorin-like protein A39 Chains: A, B
Molecule details ›
Chains: A, B
Length: 383 amino acids
Theoretical weight: 43.37 KDa
Source organism: Vaccinia virus Copenhagen
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21062 (Residues: 15-396; Coverage: 98%)
Gene name: A39R
Sequence domains: Sema domain
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-3
Spacegroup: C2221
Unit cell:
a: 51.088Å b: 171.006Å c: 211.175Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.224
Expression system: Spodoptera frugiperda

Quick links

Citations

38 review citations

Getting neural circuits into shape with semaphorins.
Pasterkamp RJ. (2012)
37 more

3 mentions without citation

How vaccinia virus has evolved to subvert the host immune response.
Bahar et al. (2011)
2 more