› 3nwh

X-ray diffraction
2.6Å resolution

Crystal structure of BST2/Tetherin

Released:
DOI: 10.2210/pdb3nwh/pdb
PDB entry 3nwh coloured by chain, front view.
PDB entry 3nwh coloured by chain, side view.
PDB entry 3nwh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.
Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP
Proc Natl Acad Sci U S A 107 17951-6 (2010)
PMID: 20880831

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q10589 (Residues: 47-152; Coverage: 59%)
Gene name: BST2
Sequence domains: Bone marrow stromal antigen 2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21
Unit cell:
a: 26.55Å b: 59.584Å c: 159.473Å
α: 90° β: 91.56° γ: 90°
R-values:
R R work R free
0.262 0.26 0.288
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

HIV Restriction Factors and Mechanisms of Evasion.
Malim et al. (2012)
20 more

11 mentions without citation

Tetherin and its viral antagonists.
Kuhl et al. (2011)
10 more