› 3o2y

X-ray diffraction
1.7Å resolution

Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid

Released:
DOI: 10.2210/pdb3o2y/pdb
PDB entry 3o2y coloured by chain, front view.
PDB entry 3o2y coloured by chain, side view.
PDB entry 3o2y coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu Z-J

Function and Biology Details

Reaction catalysed: 
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin-H2 D-isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41222 (Residues: 29-190; Coverage: 96%)
Gene names: PDS, PTGDS
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand OLA 2 x OLA
Ligand PLM 2 x PLM
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 90.221Å b: 90.221Å c: 35.635Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.264
Expression system: Escherichia coli

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