› 3olr

X-ray diffraction
2.5Å resolution

PTPN22 in complex with consensus phospho-tyrosine peptide 1

Released:
DOI: 10.2210/pdb3olr/pdb
PDB entry 3olr coloured by chain, front view.
PDB entry 3olr coloured by chain, side view.
PDB entry 3olr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yu X, Sun J-P, Zhang S, Zhang Z-Y

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163861 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 22 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 36.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2R2 (Residues: 1-294; Coverage: 36%)
Gene names: PTPN22, PTPN8
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
SKAP2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 9 amino acids
Theoretical weight: 1.25 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 45.897Å b: 62.766Å c: 117.461Å
α: 99.06° β: 96.53° γ: 105.06°
R-values:
R R work R free
0.162 0.162 0.21
Expression systems:
  • Escherichia coli
  • Not provided

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