3oq5

X-ray diffraction
2.5Å resolution

Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
PDBe Complex ID:
PDB-CPX-138129 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lethal(3)malignant brain tumor-like protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 345 amino acids
Theoretical weight: 39.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y468 (Residues: 259-598; Coverage: 41%)
Gene names: KIAA0681, L3MBT, L3MBTL, L3MBTL1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.
Cellular tumor antigen p53 Chains: D, E
Molecule details ›
Chains: D, E
Length: 10 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 377-386; Coverage: 3%)
Gene names: P53, TP53

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P32
Unit cell:
a: 109.08Å b: 109.08Å c: 90.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided