› 3owk

X-ray diffraction
1.8Å resolution

Human CK2 catalytic domain in complex with a benzopyridoindole derivative inhibitor

Released:
DOI: 10.2210/pdb3owk/pdb
PDB entry 3owk coloured by chain, front view.
PDB entry 3owk coloured by chain, side view.
PDB entry 3owk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.
Prudent R, Moucadel V, Nguyen CH, Barette C, Schmidt F, Florent JC, Lafanechère L, Sautel CF, Duchemin-Pelletier E, Spreux E, Filhol O, Reiser JB, Cochet C
Cancer Res 70 9865-74 (2010)
PMID: 21118972

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 39.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-331; Coverage: 85%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 18E 1 x 18E
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 58.489Å b: 46.362Å c: 63.942Å
α: 90° β: 111.47° γ: 90°
R-values:
R R work R free
0.22 0.219 0.262
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Casein kinase: the triple meaning of a misnomer.
Venerando et al. (2014)
11 more

1 mention without citation

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design.
Cozza G. (2017)