› 3p2t

X-ray diffraction
1.7Å resolution

Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)

Released:
DOI: 10.2210/pdb3p2t/pdb
PDB entry 3p2t coloured by chain, front view.
PDB entry 3p2t coloured by chain, side view.
PDB entry 3p2t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.
Cheng H, Mohammed F, Nam G, Chen Y, Qi J, Garner LI, Allen RL, Yan J, Willcox BE, Gao GF
J Biol Chem 286 18013-25 (2011)
PMID: 21454581

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte immunoglobulin-like receptor subfamily B member 4 Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 21.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NHJ6 (Residues: 24-219; Coverage: 46%)
Gene names: ILT3, LILRB4, LIR5
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 61.863Å b: 61.863Å c: 115.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.218
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Kang et al. (2016)
11 more

4 mentions without citation

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
Deng et al. (2018)
3 more