Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- LDLR class B repeat
- EGF-like domain
- Low-density lipoprotein (LDL) receptor class A repeat
- EGF-like calcium-binding domain
- Peptidase S8, subtilisin-related
- EGF-type aspartate/asparagine hydroxylation site
- Peptidase S8/S53 domain superfamily
- Peptidase S8 propeptide/proteinase inhibitor I9
11 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
LDLR-PCSK9 complex (preferred)
PDBe Complex ID:
PDB-CPX-134047 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: P
Length: 92 amino acids
Theoretical weight: 10.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Peptidase inhibitor I9
Length: 92 amino acids
Theoretical weight: 10.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q8NBP7 (Residues: 61-152; Coverage: 14%)
Sequence domains: Peptidase inhibitor I9
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: A
Length: 540 amino acids
Theoretical weight: 57.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 540 amino acids
Theoretical weight: 57.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Sequence domains:
Low-density lipoprotein receptor
Molecule details ›
Chain: L
Length: 440 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 440 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P01130 (Residues: 276-715; Coverage: 52%)
Sequence domains:
