› 3p7c

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 2-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand BOG 1 x BOG
Ligand P7C 1 x P7C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 66.86Å b: 70.77Å c: 76.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.234 0.292
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein crystallography and fragment-based drug design.
Caliandro et al. (2013)
1 more

2 mentions without citation

Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
Da et al. (2019)
1 more