› 3p9z

X-ray diffraction
2.1Å resolution

Crystal structure of uroporphyrinogen-III synthetase from Helicobacter pylori 26695

Released:
DOI: 10.2210/pdb3p9z/pdb
PDB entry 3p9z coloured by chain, front view.
PDB entry 3p9z coloured by chain, side view.
PDB entry 3p9z coloured by chain, top view.
Source organism: Helicobacter pylori
Entry authors: Nocek B, Stein A, Chhor G, Fenske RJ, Buck K, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
Hydroxymethylbilane = uroporphyrinogen III + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen-III synthase Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 26.31 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli
UniProt:
  • Canonical: O25822 (Residues: 1-226; Coverage: 100%)
Gene name: HP_1224
Sequence domains: Uroporphyrinogen-III synthase HemD
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand MLI 1 x MLI
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 55.407Å b: 57.676Å c: 74.624Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.202 0.241
Expression system: Escherichia coli

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