› 3pbl

X-ray diffraction
2.89Å resolution

Structure of the human dopamine D3 receptor in complex with eticlopride

Released:
DOI: 10.2210/pdb3pbl/pdb
PDB entry 3pbl coloured by chain, front view.
PDB entry 3pbl coloured by chain, side view.
PDB entry 3pbl coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.
Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC
Science 330 1091-5 (2010)
PMID: 21097933

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
D(3) dopamine receptor; Endolysin Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 53.65 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35462 (Residues: 2-221, 319-400; Coverage: 76%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: DRD3, E
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand ETQ 2 x ETQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 88.828Å b: 92.492Å c: 176.116Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.272
Expression system: Spodoptera frugiperda

Quick links

Citations

126 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
125 more

246 mentions without citation

Diversity and modularity of G protein-coupled receptor structures.
Katritch et al. (2012)
245 more