› 3pdv

X-ray diffraction
2.2Å resolution

Structure of the PDlim2 PDZ domain in complex with the C-terminal 6-peptide extension of NS1

Released:
DOI: 10.2210/pdb3pdv/pdb
PDB entry 3pdv coloured by chain, front view.
PDB entry 3pdv coloured by chain, side view.
PDB entry 3pdv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1.
Yu J, Li X, Wang Y, Li B, Li H, Li Y, Zhou W, Zhang C, Wang Y, Rao Z, Bartlam M, Cao Y
PLoS One 6 e19511 (2011)
PMID: 21625420

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PDZ and LIM domain protein 2 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96JY6 (Residues: 1-87; Coverage: 25%)
Gene names: PDLIM2, PP6345
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: I23
Unit cell:
a: 81.917Å b: 81.917Å c: 81.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.249
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.
Javier et al. (2011)
11 more

4 mentions without citation

Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.
Blake et al. (2023)
3 more