› 3pg7

X-ray diffraction
2.19Å resolution

Crystal structure of the H. sapiens NF1 SEC-PH domain (del1750 mutant)

Released:
DOI: 10.2210/pdb3pg7/pdb
PDB entry 3pg7 coloured by chain, front view.
PDB entry 3pg7 coloured by chain, side view.
PDB entry 3pg7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.
Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K
Hum Mutat 32 191-7 (2011)
PMID: 21089070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurofibromin Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21359 (Residues: 1581-1837; Coverage: 9%)
Gene name: NF1
Sequence domains: Divergent CRAL/TRIO domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PTY 2 x PTY
Ligand POP 2 x POP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 113.44Å b: 113.44Å c: 124.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.249
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms.
Carroll SL. (2012)
3 more

4 mentions without citation

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.
Kiel et al. (2014)
3 more