› 3pnr

X-ray diffraction
2.6Å resolution

Structure of PbICP-C in complex with falcipain-2

Released:
DOI: 10.2210/pdb3pnr/pdb
PDB entry 3pnr coloured by chain, front view.
PDB entry 3pnr coloured by chain, side view.
PDB entry 3pnr coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.
Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R
Structure 19 919-29 (2011)
PMID: 21742259

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-223946 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Falcipain-2a Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.03 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I6U4 (Residues: 245-484; Coverage: 50%)
Gene names: FP-2, FP2, FP2A, PF3D7_1115700
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases
PbICP-C Chain: B
Molecule details ›
Chain: B
Length: 187 amino acids
Theoretical weight: 21.24 KDa
Source organism: Plasmodium berghei
Expression system: Escherichia coli
Structure domains: Immunoglobulin-like

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand CD 2 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P43
Unit cell:
a: 71.15Å b: 71.15Å c: 120.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.229
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Molecular recognition in chemical and biological systems.
Persch et al. (2015)
10 other articles

7 mentions without citation

Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets.
Verma et al. (2016)
6 more