› 3pos

X-ray diffraction
1.65Å resolution

Crystal structure of the globular domain of human calreticulin

Released:
DOI: 10.2210/pdb3pos/pdb
PDB entry 3pos coloured by chain, front view.
PDB entry 3pos coloured by chain, side view.
PDB entry 3pos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.
Chouquet A, Païdassi H, Ling WL, Frachet P, Houen G, Arlaud GJ, Gaboriaud C
PLoS One 6 e17886 (2011)
PMID: 21423620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151073 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calreticulin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 265 amino acids
Theoretical weight: 30.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27797 (Residues: 18-204, 302-368; Coverage: 64%)
Gene names: CALR, CRTC
Sequence domains: Calreticulin family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 42.23Å b: 91.1Å c: 194.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.205
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Calreticulin in the immune system: ins and outs.
Raghavan et al. (2013)
8 more

9 mentions without citation

Calnexin cycle - structural features of the ER chaperone system.
Kozlov et al. (2020)
8 more