› 3q6n

X-ray diffraction
3.05Å resolution

Crystal Structure of Human MC-HSP90 in P21 space group

Released:
DOI: 10.2210/pdb3q6n/pdb
PDB entry 3q6n coloured by chain, front view.
PDB entry 3q6n coloured by chain, side view.
PDB entry 3q6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The hexameric structures of human heat shock protein 90.
Lee CC, Lin TW, Ko TP, Wang AH
PLoS One 6 e19961 (2011)
PMID: 21647436

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 448 amino acids
Theoretical weight: 52.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 293-732; Coverage: 60%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Hsp90 protein
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 157.897Å b: 90.868Å c: 167.093Å
α: 90° β: 115.85° γ: 90°
R-values:
R R work R free
0.207 0.204 0.259
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.
Ciocca et al. (2013)
5 more

7 mentions without citation

The hexameric structures of human heat shock protein 90.
Lee et al. (2011)
6 more