› 3q6o

X-ray diffraction
2.05Å resolution

Oxidoreductase Fragment of Human QSOX1

Released:
DOI: 10.2210/pdb3q6o/pdb
PDB entry 3q6o coloured by chain, front view.
PDB entry 3q6o coloured by chain, side view.
PDB entry 3q6o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The dynamic disulphide relay of quiescin sulphydryl oxidase.
Alon A, Grossman I, Gat Y, Kodali VK, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D
Nature 488 414-8 (2012)
PMID: 22801504

Function and Biology Details

Reaction catalysed: 
2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfhydryl oxidase 1 Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 27.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00391 (Residues: 33-272; Coverage: 33%)
Gene names: QSCN6, QSOX1, UNQ2520/PRO6013
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
1 modified residue:
Ligand MLY 5 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 56.17Å b: 65.25Å c: 68.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.261
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.
Sun et al. (2015)
12 more

9 mentions without citation

The dynamic disulphide relay of quiescin sulphydryl oxidase.
Alon et al. (2012)
8 more