› 3qak

X-ray diffraction
2.71Å resolution

Agonist bound structure of the human adenosine A2a receptor

Released:
DOI: 10.2210/pdb3qak/pdb
PDB entry 3qak coloured by chain, front view.
PDB entry 3qak coloured by chain, side view.
PDB entry 3qak coloured by chain, top view.
Source organisms:
Primary publication:
Structure of an agonist-bound human A2A adenosine receptor.
Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC
Science 332 322-7 (2011)
PMID: 21393508

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 54.74 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-208, 222-316; Coverage: 73%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: ADORA2, ADORA2A, E
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand UKA 1 x UKA
Ligand OLC 2 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 47.836Å b: 78.944Å c: 86.579Å
α: 90° β: 100.54° γ: 90°
R-values:
R R work R free
0.22 0.217 0.273
Expression system: Spodoptera frugiperda

Quick links

Citations

107 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
106 more

146 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
145 more