› 3qm4

X-ray diffraction
2.85Å resolution

Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex

Released:
DOI: 10.2210/pdb3qm4/pdb
PDB entry 3qm4 coloured by chain, front view.
PDB entry 3qm4 coloured by chain, side view.
PDB entry 3qm4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human cytochrome P450 2D6 with prinomastat bound.
Wang A, Savas U, Hsu MH, Stout CD, Johnson EF
J Biol Chem 287 10834-43 (2012)
PMID: 22308038

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2D6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 479 amino acids
Theoretical weight: 53.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli DH5[alpha]
UniProt:
  • Canonical: P10635 (Residues: 34-497; Coverage: 93%)
Gene names: CYP2D6, CYP2DL1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

3 bound ligands:
Ligand HEM 2 x HEM
Ligand PN0 2 x PN0
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 194.54Å b: 55.07Å c: 145.87Å
α: 90° β: 134.97° γ: 90°
R-values:
R R work R free
0.245 0.243 0.288
Expression system: Escherichia coli DH5[alpha]

Quick links

Citations

9 review citations

A Review of the Important Role of CYP2D6 in Pharmacogenomics.
Taylor et al. (2020)
8 more

30 mentions without citation

Recent Structural Insights into Cytochrome P450 Function.
Guengerich et al. (2016)
29 more