› 3qo4

X-ray diffraction
2.2Å resolution

The Crystal Structure of Death Receptor 6

Released:
DOI: 10.2210/pdb3qo4/pdb
PDB entry 3qo4 coloured by chain, front view.
PDB entry 3qo4 coloured by chain, side view.
PDB entry 3qo4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP).
Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME
J Mol Biol 409 189-201 (2011)
PMID: 21463639

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131001 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 21 Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 19.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75509 (Residues: 42-218; Coverage: 29%)
Gene names: DR6, TNFRSF21, UNQ437/PRO868
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P6122
Unit cell:
a: 77.91Å b: 77.91Å c: 187.844Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.215 0.261
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Identification and biology of α-secretase.
Vingtdeux et al. (2012)
2 more

6 mentions without citation

A Structural and Functional Perspective of Death Receptor 6.
Ren et al. (2022)
5 more