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F54C HLA-DR1 bound with CLIP peptide

X-ray diffraction
2.302Å resolution
PDB entry 3qxd coloured by chain, front view.
PDB entry 3qxd coloured by chain, side view.
PDB entry 3qxd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 17921.93 Å2
Buried surface area: 7102.23 Å2
Dissociation area: 1,195.74 Å2
Dissociation energy (ΔGdiss): 18.6 kcal/mol
Dissociation entropy (TΔSdiss): 8.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135318
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 17928.03 Å2
Buried surface area: 7053.45 Å2
Dissociation area: 1,170.15 Å2
Dissociation energy (ΔGdiss): 19.57 kcal/mol
Dissociation entropy (TΔSdiss): 8.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135318

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, D
Length: 182 amino acids
Theoretical weight: 21.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3qxd, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3qxd, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3qxd, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, E
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3qxd, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3qxd, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3qxd, assembly 1, top view.
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Class-II-associated invariant chain peptide
Chains: C, F
Length: 15 amino acids
Theoretical weight: 1.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04233 (Residues: 103-117; Coverage: 5%)
Gene names: CD74, DHLAG
Class-II-associated invariant chain peptide in PDB entry 3qxd, assembly 1, front view.
Class-II-associated invariant chain peptide in PDB entry 3qxd, assembly 1, side view.
Class-II-associated invariant chain peptide in PDB entry 3qxd, assembly 1, top view.
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