› 3qxl

X-ray diffraction
2.24Å resolution

Crystal structure of the CDC25 Domain from Ral-specific Guanine-nucleotide Exchange Factor RalGPS1a

Released:
DOI: 10.2210/pdb3qxl/pdb
PDB entry 3qxl coloured by chain, front view.
PDB entry 3qxl coloured by chain, side view.
PDB entry 3qxl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
Peng W, Xu J, Guan X, Sun Y, Zhang XC, Li X, Rao Z
Protein Cell 2 308-19 (2011)
PMID: 21494904

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-specific guanine nucleotide-releasing factor RalGPS1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5JS13 (Residues: 23-289; Coverage: 48%)
Gene names: KIAA0351, RALGEF2, RALGPS1
Sequence domains: RasGEF domain
Structure domains: Ras guanine-nucleotide exchange factors catalytic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P21
Unit cell:
a: 36.504Å b: 102.035Å c: 82.141Å
α: 90° β: 96.54° γ: 90°
R-values:
R R work R free
0.199 0.197 0.24
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
3 other articles

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)