› 3r1q

X-ray diffraction
1.85Å resolution

CDK2 in complex with inhibitor KVR-1-102

Released:
DOI: 10.2210/pdb3r1q/pdb
PDB entry 3r1q coloured by chain, front view.
PDB entry 3r1q coloured by chain, side view.
PDB entry 3r1q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Betzi S, Alam R, Han H, Becker A, Schonbrunn E

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand X75 1 x X75
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 53.64Å b: 71.54Å c: 72.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.237
Expression system: Escherichia coli

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