› 3rn8

X-ray diffraction
1.7Å resolution

Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator

Released:
DOI: 10.2210/pdb3rn8/pdb
PDB entry 3rn8 coloured by chain, front view.
PDB entry 3rn8 coloured by chain, side view.
PDB entry 3rn8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Timm DE, Benveniste M, Weeks AM, Nisenbaum ES, Partin KM
Mol Pharmacol 80 267-80 (2011)
PMID: 21543522

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 280 amino acids
Theoretical weight: 30.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42262 (Residues: 413-527, 653-812; Coverage: 32%)
Gene names: GLUR2, GRIA2, GluA2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

5 bound ligands:
Ligand GLU 3 x GLU
Ligand RN8 2 x RN8
Ligand ZN 5 x ZN
Ligand ACT 2 x ACT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 113.889Å b: 163.232Å c: 47.356Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.224
Expression system: Escherichia coli

Quick links

Citations

5 review citations

AMPA receptor potentiators: from drug design to cognitive enhancement.
Partin KM. (2015)
4 more

3 mentions without citation

Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Timm et al. (2011)
2 more